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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Lyme disease
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Accession:DOID:11729 term browser browse the term
Definition:A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. (DO)
Synonyms:exact_synonym: Bannwarth syndrome;   Bannworth's syndrome;   Lyme Arthritis;   Lyme Borreliosis;   lyme neuroborreliosis;   neuroborreliosis;   neurological Lyme disease
 primary_id: MESH:D008193
 xref: EFO:0008510;   GARD:12073;   ICD10CM:A69.2;   ICD9CM:088.81;   NCI:C45161
For additional species annotation, visit the Alliance of Genome Resources.

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Lyme disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl20 C-C motif chemokine ligand 20 ISO protein:increased expression:synovial fluid RGD PMID:23371320 RGD:7488895 NCBI chrNW_004624843:2,017,738...2,021,153 JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:21387014 RGD:5508754 NCBI chrNW_004624757:5,956,873...6,000,052
Ensembl chrNW_004624757:5,958,486...6,000,103 		JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO mRNA:increased expression:skin RGD PMID:19461880 RGD:6483813 NCBI chrNW_004624907:1,174,648...1,188,919
Ensembl chrNW_004624907:1,174,448...1,189,377 		JBrowse link
Lyme Neuroborreliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004624790:8,475,640...8,485,927
Ensembl chrNW_004624790:8,476,158...8,485,856 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16463218 RGD:11352252 NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338 		JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 treatment ISO RGD PMID:24239846 RGD:39939054 NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23134838 RGD:7193053 NCBI chrNW_004624749:12,852,128...12,858,478
Ensembl chrNW_004624749:12,852,021...12,858,760 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14088
    disease by infectious agent 1899
      Bacterial Infections and Mycoses 917
        bacterial infectious disease 722
          primary bacterial infectious disease 159
            Lyme disease 7
              Erythema Chronicum Migrans 0
              Lyme Neuroborreliosis 4
              Post-Lyme Disease Syndrome 0
Path 2
Term Annotations click to browse term
  disease 14088
    disease by infectious agent 1899
      Bacterial Infections and Mycoses 917
        bacterial infectious disease 722
          Spirochaetales Infections 17
            Borrelia Infections 7
              Lyme disease 7
                Erythema Chronicum Migrans 0
                Lyme Neuroborreliosis 4
                Post-Lyme Disease Syndrome 0
paths to the root